Publications

Latest articles in international journals with refereeing

2013

21) Sérgio M. Marques, Claudia Abate, Sílvia Chaves, Fernanda Marques, Isabel Santos, Elisa Nuti, Armando Rossello, M. Amélia Santos, "New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy", J. Inorg. Biochem. 2013,to be published ASAP.
DOI: 10.1016/j.jinorgbio.2013.03.003

20) Andreia Nunes, Sérgio M. Marques, Catarina Quintanova, Diana F. Silva, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos, "Multifunctional iron-chelators with protective roles against neurodegenerative diseases", Dalton Trans. 2013, 42, 6058–6073.
DOI: 10.1039/c3dt50406a

19) Ana C. Mendonça, André F. Martins, Andrea Melchior, Sérgio M. Marques, Sílvia Chaves, Sandrine Villette, Stéphane Petoud, Pier Luigi Zanonato, Marilena Tolazzi, Célia S. Bonnet, Éva Tóth, Plinio Di Bernardo, Carlos F.G.C. Geraldes, M. Amélia Santos, "New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties", Dalton Trans. 2013, 42, 6046-6057.
DOI: 10.1039/C2DT32237D

18) Sílvia Chaves, Anabela Capelo, Laurinda Areias,Sérgio M. Marques, Lurdes Gano, M. Alexandra Esteves, M. Amélia Santos, "A novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: synthesis, complexation and in vivo studies", Dalton Trans. 2013, 42, 6033-6045.
DOI: 10.1039/C2DT32361C

2012

17) M. Amélia Santos, Sérgio M. Marques, Sílvia Chaves, “Hydroxypyridinones as “privileged” chelating structures for the design of medicinal drugs”, Coord. Chem. Rev. 2012, 256, 240-259.
DOI: 10.1016/j.ccr.2011.08.008

2011

16) Sérgio M. Marques, Tiziano Tuccinardi, Elisa Nuti, Salvatore Santamaria, Vânia André, Armando Rossello, Adriano Martinelli, and M. Amélia Santos, "1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases”, J. Med. Chem. 2011, 54, 8289-8298.
DOI: 10.1021/jm200593b

15) Jaroslav Šebestík, Sérgio M. Marques, Pedro L. Falé, Susana Santos, Daniela M. Arduíno, Sandra M. Cardoso, Catarina R. Oliveira, M. Luísa M. Serralheiro, M. Amélia Santos, “Bifunctional phenolic-choline conjugates as anti-oxidant and acetylcholinesterase inhibitors”, J. Enzym. Inhib. Med. Ch. 2011, 26, 485-497.
DOI: 10.3109/14756366.2010.529806

14) Sílvia Chaves, Ana C. Mendonça, Sérgio M. Marques, M. Isabel Prata, Ana C. Santos, André F. Martins, Carlos F.G.C. Geraldes, M. Amélia Santos, “A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging: solution and in vivo studies of 67Ga-labeled species”, J. Inorg. Biochem. 2011, 105, 31-38.
DOI: 10.1016/j.jinorgbio.2010.09.012

2010 and earlier

13) Sílvia Chaves, Sérgio M. Marques, André M.F. Matos, Andreia Nunes, Lurdes Gano, Tiziano Tuccinardi, Adriano Martinelli, M. Amélia Santos, "New tris-hydroxypyridinones as iron and aluminum sequestering agents. Synthesis, complexation and in vivo studies”, Chem.-Eur. J. 2010, 16, 10535-10545.
DOI: 10.1002/chem.201001335

12) Sérgio M. Marques, Éva A. Enyedy, Claudiu T. Supuran, Natalia I. Krupenko, Sergey A. Krupenko and M. Amélia Santos, “Pteridine–sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity”, Bioorg. Med. Chem. 2010, 18, 5081-5089.
DOI: 10.1016/j.bmc.2010.05.072

11) M. Alexandra Esteves, Osvaldo Ortet, Anabela Capelo, Claudiu T. Supuran, Sérgio M. Marques and M. Amélia Santos, “New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors”, Bioorg Med. Chem. Lett. 2010, 20, 3623-3627.
DOI: 10.1016/j.bmcl.2010.04.109

10) Tiziano Tuccinardi, Gabriella Ortore, M. Amélia Santos, Sérgio M. Marques, Elisa Nuti, Armando Rossello and Adriano Martinelli, “Multitemplate alignment method for the development of a reliable 3D-QSAR model for the analysis of MMP3 inhibitors”, J. Chem. Inf. Model. 2009, 49, 1715-1724.
DOI: 10.1021/ci900118v

9) Sérgio M. Marques, Elisa Nuti, Armando Rossello, Claudiu T. Supuran, Tiziano Tuccinardi, Adriano Martinelli and M. Amélia Santos, “Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl based hydroxamate-benzenesulfonamide conjugates”, J. Med. Chem. 2008, 51, 7968-7979.
DOI: 10.1021/jm800964f

Patents

2) Sérgio M. Marques, Armando Rossello, M. Amélia Santos, “New inhibitors of metalo-enzymes with potential clinical application: 1-hydroxy-piperazino-2,6-dione derivatives as a new zinc-binding group”, PT 103897, 2008.

1) M. Amélia Santos, Sérgio M. Marques, Marco Gil, Matteo Tegoni, Sílvia Chaves, “Set of medicinal metal enzyme high capacity inhibitors comprises succinic and iminodiacetic acids giving high zinc and nickel ion complexing capacity”, PT 103003, 2005.

Conference proceedings with scientific refereeing

2) Sérgio M. Marques, Sílvia Chaves, Armando Rossello, Tiziano Tuccinardi and M. Amélia Santos, “Iminodiacetyl-monohydroxamate derivatives as potent and selective MMP inhibitors”, Metal Ions in Biology and Medicine, John Libbey Eurotext: Paris, 2006, Vol. 9, p. 117-121.

1) M. Amélia Santos, Marco Gil, Sérgio Marques, M. Lurdes Gano, Sílvia Chaves, “Complexation of three N-carboxyalkyl derivatives of 3-hydroxy-4-pyridinones with Fe(III), Al(III), Ga(III) and In(III). Studies in vitro and in vivo”, Metal Ions in Biology and Medicine, John Libbey Eurottext: Paris, 2002, Vol. 7, pp 655-658.