José Paulo Sequeira Farinha

Professor

   
Department of Chemical Engineering
Instituto Superior Técnico
University of Lisbon
Centro de Química Estrutural and
Institute of Nanoscience and Nanotechnology

address:
CQE, IST,
Av. Rovisco Pais 1
1049-001 Lisboa, Portugal

phone: (+351) 218 419 221

email: farinha @ tecnico.ulisboa.pt


   

 

►Education

Research Interests

Team

Patents

Articles in Refereed International Journals

Books

Teaching


 
           

Biotin-End-Functionalized Highly Fluorescent Water-Soluble Polymers
Relogio,P.; Bathfield, M.; Haftek-Terreau, Z.; Beija, M.; D’Agosto, F.; Favier, A.; Giraud-Panis, M.-J.; Mandrand, B.; Farinha, J. P. S.*.; Charreyre, M.-T.;* Martinho, J. M. G.,
Polym. Chem., 2013, 4, 2968–2981.
(dx.doi.org/10.1039/C3PY00059A


The cover image is a reproduction of the painting "Lucifer Yellow" by Ana Tristany. Four polymer chains (blue) labeled with several LY fluorophores (yellow), each with a biotin at one chain-end (blue/black) interact with a streptavidine protein (red).

 

Resonance Energy Transfer in Polymer Nanodomains (Review Article)
Martinho, J. M. G.; Farinha, J. P. S.,
Journal of Physical Chemistry C, 2008, 112, 10591-10601.
(
dx.doi.org/10.1021/jp8016437)


The cover is a reproduction of the painting "Interfaces" (acrylic on canvas, 1.5 m x 1.5 m) by Ana Tristany. Nano-size domains located at the interface between different polymers (in black and grey) are labeled with energy donor (red) and acceptor (green) dyes
.

         
               
               

Smart Materials for Boron Removal
Alves,S.; Santos,C.I.; da Costa,A.P.; Silva,M.; Baleizão*,C.; Farinha,J.P.S.*
Chemical Engineering Journal
2017, 319, 31–33
(
dx.doi.org/10.1016/j.cej.2017.02.139)

The cover shows a novel boron scavenging process. At room temperature the nanoparticlesare expanded, promoting boron chelation to diol groups. At higher temperature the polymer shell collapses inducing nanoparticle flocculation. The nanoparticles can then be regenerated by pH treatment and reused. 

A Cationic Smart Copolymer for DNA Binding
Ribeiro,T.; Santiago,A.M.; Martinho,J.M.G.; Farinha,J.P.S.*
Polymers 2017, 11, 576
(dx.doi.org/10.3390/polym9110576)

A new copolymer with a temperature-responsive block and a cationic block forms coacervate complexes with the DNA. The new materials offer good prospects for application in controlled gene delivery.

         
               

Education

Post-doctoral fellow at the Department of Chemistry of the University of Toronto, Canada (Colloid and Polymer Chemistry Group, M. A. Winnik, 1997 - 1999)
PhD on Chemical Engineering (Technical University of Lisbon, 1996)
Graduated in Chemical Engineering (Instituto Superior Técnico, 1990)


Research Interests

Major Fields of Interest

Research and development of novel advanced functional materials, in particular nanostructured materials, featuring significant interaction with light, with applications in the energy, biomedical and environmental fields.

 

Key areas:

- Functinal nanomaterials;

- Nanoparticles;

- Polymers and Colloids;

- Emulsion and miniemulsion polymerization;

- Controled radical polymerization;

- Polymer coatings;

- Optical sensor nanomaterials;

- Fluorescence applications and laser scanning microscopy.

 

Nanomaterials for Imaging and Diagnostics

The use of fluorescent molecules is currently the most common labelling technique in biosensing and bioimaging for the detection of disease biomarkers.

Multifunctional Hybrid Nanoparticles encapsulating fluorophores yield high brightness photostable labels for biosensing and laser scanning microscopy. The particles can be surface-decorated with sensor and/or cancer tissue/cell targeting groups.

 

 

RSC Advances 2013, 3, 9171-9174 (dx.doi.org/10.1039/C3RA41199K)

Dyes and Pigments, 2014, 110, 227-234 (dx.doi.org/10.1016/j.dyepig.2014.03.026)

 

Bio-functionalyzed highly fluorescent polymers for biodyagnostics and tumor highlighting during surgery.

 

Polymer Chemistry 2013, 4, 2968-2981 (dx.doi.org/10.1039/C3PY00059A)

Patented.

 

 

Smart Nanoparticles

Stimuli-responsive nanoparticles for biomedical and environmental aplications diagnosis and separation

 

Phys. Chem. Chem. Phys. 2016, 18, 31711-31724 (dx.doi.org/10.1039/c6cp06880d)

Langmuir, 2015, 31 , 4779-4790 (dx.doi.org/10.1021/acs.langmuir.5b00530)

J. Phys. Chem. B, 2014, 118, 3192−3206 (dx.doi.org/10.1021/jp408390t)

Langmuir 2013, 29, 13821-13835 (dx.doi.org/10.1021/la403106m)

Langmuir 2012, 28, 5802-5809 (dx.doi.org/10.1021/la2045477)

 

Polymer 2017, 116, 261-267 (dx.doi.org/10.1016/j.polymer.2017.03.071)

 

Detection of DNA hybridization

ChemPhysChem 2010, 11, 1749-1756 (dx.doi.org/10.1002/cphc.201000015)

Pure and Applied Chem. 2009, 81, 1615-1634 (dx.doi.org/10.1351/PAC-CON-08-11-11)

J. Phys. Chem. C 2008, 112, 16331 (dx.doi.org/10.1021/jp804747b)

 

Antibody separation with magnetic polymer nanoparticles

Biotechnology J. 2013, 8, 709-717 (dx.doi.org/10.1002/biot.201200329)

 

Boron scavenging

 

Chemical Engineering Journal 2017, 319, 31–33 (dx.doi.org/10.1016/j.cej.2017.02.139)

Materials and Design 2018, 141, 407–413 (dx.doi.org/10.1016/j.matdes.2018.01.001)

 

Nanostructured Hybrid Aerogel Insulation

Novel sol-gel route to prepare monolithic hybrid silica/polymer aerogels, stable under atmospheric conditions

J. Materials Chemistry 2007, 17, 2195 (dx.doi.org/10.1039/b703631k)
Chemistry of Materials 2007, 19, 2603 (dx.doi.org/10.1021/cm062962w)
Langmuir 2007, 23, 5727 (dx.doi.org/10.1021/la063381o)
Patented.

Flexible hybrid aerogels prepared under Subcritical conditions.

J. Materials Chemistry A 2013, 1, 12044-12052 (dx.doi.org/10.1039/C3TA12431B)
Patented.

Hierarchical Nanomaterials for Structural Color

Recently funded project for the design of low-cost, non-toxic structural color pigments. These non-fading environment-friendly dyes are intended for application in reflective full-color displays, printing, coatings, cosmetics, etc.

Structural color is profusely found in nature, originating from the interaction of light with periodically arranged structures of dielectric materials in length-scales ca. half the wavelength of visible light .

   

 

Materials for Theranostics

Mesoporous Hybrid Nanoparticles (MSNs) with well-defined and controllable pore and particle morphologies can carry huge drug payloads. Covalently-linked fluorophores aligned on the pore walls for imaging and a biocompatible stimuli-responsive polymer-based gate system for controlled drug release. The polymeric shell can be modified with dyes, sensor molecules and tumor-targeting ligands (e.g., oligopeptides with RGD motif, folic acid, etc.).

 

     

 

Eur. J. Inorg. Chem., 2015 (dx.doi.org/10.1002/ejic.201500580)

Microscopy and Microan., 2013, 19, 1216-1221 (dx.doi.org/10.1017/S1431927613001517)

Nanomedicine, 2015 (dx.doi.org/10.2217/NNM.15.102)
Nanoscale 2017, 36, 13485-13494 (dx.doi.org/10.1039/c7nr03395h)

 

 

High Performance Coatings

Hybrid silica-polymer nanoparticles for high-performance environmentally friendly polymer coatings

 

Materials, 2014, 7, 3881-3900 (dx.doi.org/10.3390/ma7053881)

CoatingsTech 2013, 10, 46-53 (ISSN 1547-0083, coatingstech/201309#pg44)

 


 

J. Phys. Chem. C 2009, 113, 18082-18090 (dx.doi.org/10.1021/jp906748r)

J. Coll. Int. Sci. 2013, 401, 14-22 (dx.doi.org/10.1016/j.jcis.2013.03.002)
 

Langmuir 2014, 30, 12345-12353 (dx.doi.org/10.1021/la502826r)
J. Coll. Int. Sci.2012, 368, 21-33 (dx.doi.org/10.1016/j.jcis.2011.10.077)
Patented.

 

 

Optical sensors

Development of new optical fluorescent sensors supported in polymers and nanoparticles


Journal of Materials Chemistry 2010, 20, 1192-1197 (dx.doi.org/10.1039/B920673F)

Patented

 

New optical sensors for Boron detection in water

    

Analytical Methods, 2014, 6, 5450-5453 (dx.doi.org/10.1039/c4ay00236a)

RSC Advances 2017, 7, 4627 (dx.doi.org/10.1039/C6RA25022J)

Patented.

 

Metal Nanoparticle Enhanced Emission

Metal NPs act as nanoantennas when they are excited by light in resonance with their characteristic plasmon modes, and can enhance the emission of nearby fluorophores

Micellar assemblies of quantum dots and metal nanoparticles

  

J. Phys. Chem. C 2013, 117, 3122-3133 (dx.doi.org/10.1021/jp311200r)

Langmuir 2017, 33, 8201-8212 (dx.doi.org/10.1021/acs.langmuir.7b01687)

  

Core-shell gold-silica nanoparticles surface-decorated with fluorophores

  

Nature Scientific Reports 2017, 7, 2440 (dx.doi.org/10.1038/s41598-017-02678-0)


Teaching

 

Director of the Integrated MSc program in Materials Engineering, IST

Member of the Scientific Commission of the Integrated MSc program in Biomedical Engineering, IST

 

Courses:

Nanostructured Materials and Nanotechnology (Master program in Materials Engineering)

Polymeric Materials (Master program in Materials Engineering)

Surfaces, Interfaces and Colloids (PhD programs, Master program in BioEngineering and Nanosystems)

Advanced Topics in Nanotechnology (PhD program in Materials Engineering)

Materials for Regenerative Medicine (FCT PhD program in Bioengineering – Cell Therapies and Regenerative Medicine

Chemical Engineering Lab (Master program in Chemical Engineering)

Project I & II (Master program in Chemical Engineering)

Physical Chemistry (Master programs in Biological Engineering and in Chemical Engineering)

General Chemistry


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