José Paulo Sequeira Farinha

Professor of Physical Chemistry, Materials and Nanoscience

   

Department of Chemical Engineering
Instituto Superior Técnico
University of Lisbon
Centro de Química-Física Molecular
Institute of Nanoscience and Nanotechnology

address:
CQFM-IST,
Av. Rovisco Pais 1
1049-001 Lisboa, Portugal

phone: (+351) 218 419 221

email: farinha @ tecnico.ulisboa.pt


 

►Education

Research Interests

Team

Patents

Articles in Refereed International Journals

Books

Invited Oral Communications

International Conference Proceedings

Papers in National Journals and Conferences

Teaching


 
   

Biotin-End-Functionalized Highly Fluorescent Water-Soluble Polymers
Relogio,P.; Bathfield, M.; Haftek-Terreau, Z.; Beija, M.; D’Agosto, F.; Favier, A.; Giraud-Panis, M.-J.; Mandrand, B.; Farinha, J. P. S.*.; Charreyre, M.-T.;* Martinho, J. M. G.,
Polym. Chem.,
2013, 4, 2968–2981.
(http://dx.doi.org/10.1039/C3PY00059A)

Reproduction of the painting "Lucifer Yellow" by Ana Tristany.
The cover image is a reproduction of the painting "Lucifer Yellow" by Ana Tristany , of four polymer chains (blue) labeled with several LY fluorophores (yellow), each with a biotin at one chain-end (blue/black). The biotin groups are in the process of interacting with a streptavidine protein (red).

 

Resonance Energy Transfer in Polymer Nanodomains (Review Article)
Martinho, J. M. G.; Farinha, J. P. S.,
Journal of Physical Chemistry C,
2008, 112, 10591-10601.
(http://dx.doi.org/10.1021/jp8016437
)

Reproduction of the painting "Interfaces" by Ana Tristany.
The cover is a reproduction of the painting "Interfaces" (acrylic on canvas, 1.5 m x 1.5 m), a personal interpretation by artist Ana Tristany of nano-size domains located at the interface between different polymers (in black and grey), labeled with energy donor (red) and acceptor (green) dyes
.

 

Education

Post-doctoral fellow at the Department of Chemistry of the University of Toronto, Canada (Professor M. A. Winnik, 1997 - 1999).
PhD on Chemical Engineering (Technical University of Lisbon, 1996, supervised by Professor J. M. G. Martinho).
Graduated in Chemical Engineering (Instituto Superior Técnico, 1990).


Honors and Awards

First prize in 3M Industrial Innovation, 2001.

First prize in the Solvay Ideas Challenge competition for "AIRSILTEX Novel Insulating Hybrid Silica/Latex Aerogels", 2003.

Visiting Professor, Department of Chemistry, University of Toronto, 2002


Research Interests

Major Fields of Interest

Research and development of novel advanced functional materials, in particular nanostructured materials, featuring significant interaction with light, with applications in the energy, biomedical and environmental fields.

 

Key areas involved:

- Functinal nanomaterials;

- Nanoparticles;

- Polymers and Colloids;

- Emulsion and miniemulsion polymerization;

- Controled radical polymerization (RAFT);

- Polymer coatings;

- Optical sensor nanomaterials;

- Fluorescence applications and laser scanning microscopy.

 

Nanomaterials for Imaging and Diagnostics

The use of fluorescent molecules is currently the most common labelling technique in biosensing and bioimaging for the detection of disease biomarkers.

Multifunctional Hybrid Nanoparticles encapsulating fluorophores yield high brightness photostable labels for biosensing and laser scanning microscopy. The particles can be surface-decorated with sensor and/or cancer tissue/cell targeting groups.

 

 

RSC Advances 2013, 3, 9171-9174 (dx.doi.org/10.1039/C3RA41199K)

Dyes and Pigments, 2014, 110, 227-234 (dx.doi.org/10.1016/j.dyepig.2014.03.026)

 

Bio-functionalyzed highly fluorescent polymers for biodyagnostics and tumor highlighting during surgery.

 

Polymer Chemistry 2013, 4, 2968-2981 (dx.doi.org/10.1039/C3PY00059A)

Patented: US 8133411B2 2012; EP 1899434 2008; etc

 

Materials for Theranostics

Mesoporous Hybrid Nanoparticles (MSNs) with well-defined and controllable (ordered) pore and particle morphologies can carry huge drug payloads. Covalently-linked fluorophores aligned on the pore walls for imaging and a biocompatible stimuli-responsive polymer-based gate system for controlled drug release. The polymeric shell can be modified with dyes, sensor molecules and tumor-targeting ligands (e.g., oligopeptides with RGD motif, folic acid, etc.).

 

 

Microscopy and Microanalysis, 2013, 19, 1216-1221 (dx.doi.org/10.1017/S1431927613001517)

 

 

European Journal of Inorganic Chemistry, 2015 (dx.doi.org/10.1002/ejic.201500580)

Nanomedicine, 2015 (dx.doi.org/10.2217/NNM.15.102)

 

 

Smart Polymer Nanoparticles

Stimuli-responsive nanoparticles for biomedical and environmental aplications diagnosis and separation (DNA hybridization, antibody separation, metal ion scavenging, etc...)

 

Langmuir 2013, 29, 13821-13835 (dx.doi.org/10.1021/la403106m)

Langmuir 2012, 28, 5802-5809 (dx.doi.org/10.1021/la2045477)

 

ChemPhysChem 2010, 11, 1749-1756 (dx.doi.org/10.1002/cphc.201000015)

Pure and Applied Chemistry 2009, 81, 1615-1634 (dx.doi.org/10.1351/PAC-CON-08-11-11)

J. Phys. Chem. C 2008, 112, 16331 (dx.doi.org/10.1021/jp804747b)

 

Biotechnology Journal 2013, 8, 709-717 (dx.doi.org/10.1002/biot.201200329)

 

High Performance Coatings

Hybrid silica-polymer nanoparticles for high-performance environmentally friendly polymer coatings

 

Materials, 2014, 7, 3881-3900 (dx.doi.org/10.3390/ma7053881)

CoatingsTech 2013, 10, 46-53 (ISSN 1547-0083, coatingstech/201309#pg44)

 


 

J. Phys. Chem. C 2009, 113, 18082-18090 (dx.doi.org/10.1021/jp906748r)

Journal of Colloid and Interface Science 2013, 401, 14-22 (dx.doi.org/10.1016/j.jcis.2013.03.002)
 

Langmuir 2014, 30, 12345-12353 (dx.doi.org/10.1021/la502826r)

Journal of Colloid and Interface Science 2012, 368, 21-33 (dx.doi.org/10.1016/j.jcis.2011.10.077)

Patented.

 

 

 

Nanostructured Hybrid Aerogel Insulation

Novel sol-gel route to prepare monolithic hybrid silica/polymer aerogels, stable under atmospheric conditions

J. Materials Chemistry 2007, 17, 2195 (dx.doi.org/10.1039/b703631k)
Chemistry of Materials 2007, 19, 2603 (dx.doi.org/10.1021/cm062962w)
Langmuir 2007, 23, 5727 (dx.doi.org/10.1021/la063381o)
Patented: US7737189 2010; BR200607020 2009; JP2008537570 2008; US2008188575 2008; EP1879690 2008; AU2006231371 2006; etc.

Flexible hybrid aerogels prepared under Subcritical conditions.

J. Materials Chemistry A 2013, 1, 12044-12052 (dx.doi.org/10.1039/C3TA12431B)
Patented.
 

Optical sensors

Development of new optical fluorescent sensors supported in polymers and nanoparticles


Journal of Materials Chemistry 2010, 20, 1192-1197 (dx.doi.org/10.1039/B920673F)

Patented

 

New optical sensors for Boron detection in water


Analytical Methods, 2014, 6, 5450-5453 (dx.doi.org/10.1039/c4ay00236a)

Patented

 

 

 

Hierarchical Nanomaterials for Structural Color

Recently funded project for the design of low-cost, non-toxic structural color pigments. These non-fading environment-friendly dyes are intended for application in reflective full-color displays, printing, coatings, cosmetics, etc.

Structural color is profusely found in nature, originating from the interaction of light with periodically arranged structures of dielectric materials in length-scales ca. half the wavelength of visible light .

 

Metal Nanoparticle Enhanced Emission

Metal NPs act as nanoantennas when they are excited by light in resonance with their characteristic plasmon modes, and can enhance the emission of nearby fluorophores

Micellar assemblies of quantum dots and metal nanoparticles

 

J. Phys. Chem. C 2013, 117, 3122-3133 (dx.doi.org/10.1021/jp311200r)

Core-shell gold-silica nanoparticles surface-decorated with fluorophores

 

     

Teaching

 

Professor of Physical Chemistry, Materials and Nanosciences at the Department of Chemical Engineering, Instituto Superior Técnico.

 

Nanostructured Materials and Nanotechnology

Physical Chemistry

Surfaces, Interfaces and Colloids - PhD program, Master degree in BioEngineering and Nanosystems, Master degree in Biological Engineering, Master Degree in Chemical Engineering

General Chemistry


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