GTLight-UP

Gasotrasmitters light UP thanks to fluorescent probes that combine carbon nanomaterials and molecular units responsive to the presence of the molecule of interest

  1. AIM - To design water soluble, nonlinear turn-on probes for 3D-mapping of molecules of biological interest using optical microscopy. The targets are signaling gasotransmiter (nitrous oxide; carbon monoxide  and hydrogen sulfite), biomacromolecules (DNA), ionic species.
  2. STRATEGY -Including, but not limited to, the coupling of water solubility, cell membrane penetration ability and exceptionally high nonlinear emission and photostability of carbon dots  with the sensitivity and selectivity of optimized molecular probes to built an hybrid sensor
  3. NOVELTY - C-dots will bring solubility and stability to the hybrid sensor introducing, simultaneously, a nonlinear response in the molecular probes
Mobirise

José Gaspar Martinho

Principal Investigator

Researcher at Centro de Química Estrutural of Instituto Superior Técnico, Universidade de Lisboa

Mobirise

Ermelinda Maçôas

Co-Principal Investigator

Researcher at Centro de Química Estrutural of Instituto Superior Técnico, Universidade de Lisboa

Mobirise

Maria da Graça Neves

Team leader

Researcher at  LAQV-REQUIMTE and Department of Chemistry, University of Aveiro

Mobirise

Inês Araújo

Team Leader

Researcher at Algarve Biomedical Center Research Institute (ABC-RI) and Faculty of Medicine and Biomedical Sciences, University of Algarve

Funding

The project with reference LISBOA-01-0145-FEDER-029319 is funded by Fundação para a Ciência e a Tecnologia and PT2020 with the support of  Programa Operacional Competitividade e Internacionalização, Programa Operacional da Região do Algarve (Algarve 2020) e Programa Operacional da Região de Lisboa (Lisboa) supported by Fundo Europeu de desenvolvimento regional (FEDER)

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